Sertraline HCl (SRT) oral disintegrating tablets (ODTs) were formulated using direct compression technique through a 3 x 22 factorial design. Since disintegration time is an essential pharmacopoeial test for ODTs and tablet hardness testing is important for product development, this study aimed to develop an optimized formula with adequate disintegration time and\nhardness. The effect of different types of sugar based diluents (xylitol and maltitol), disintegrating agent (Ac-Di-Sol, crospovidone (CP) and co-processed mixture of Ac-Di-Sol and crospovidone) and disintegrating agent concentration (5%, 10%) were studied. Upon evaluation of the prepared ODTs, tablets containing xylitol with 10% CP (F4) and maltitol with 10% CP (F10) and maltitol with 10% co-processed mixture (F12) appeared to have superior properties as ODTs.
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